Cloutier, Maude et Gauthier, Charles 
ORCID: https://orcid.org/0000-0002-2475-2050
(2021).
Progress toward the Development of Glycan-Based Vaccines against Campylobacteriosis
ACS Infectious Diseases
, vol. 7
, nº 5.
pp. 969-986.
DOI: 10.1021/acsinfecdis.0c00332.
Résumé
As one of the main causes of bacterial diarrhea and a major risk factor for triggering Guillain-Barre autoimmune syndrome, campylobacteriosis, that is, Campylobacter spp. infections, represents a major health issue worldwide. There is thus a pressing need for developing an effective and broad-coverage campylobacteriosis vaccine. Campylobacter jejuni, an encapsulated, multidrug resistant Gram-negative bacterium, expresses virulence-associated capsular polysaccharides (CPSs), which constitute exquisite targets for the design of glycoconjugate vaccines. In that context, synthetic carbohydrate chemistry acts as a crucial enabling technology for the preparation of homogeneous constructs while allowing antigenic epitopes to be deciphered and probed at the molecular level. This review aims at covering recent developments in CPS-based campylobacteriosis vaccines as well as in the total syntheses of C. jejuni-related mono- and oligosaccharide mimics.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 15 juill. 2021 00:43 |
| Dernière modification: | 15 févr. 2022 17:32 |
| URI: | https://espace.inrs.ca/id/eprint/11564 |
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