N-phenyl-1-naphthylamine (PNA) Accumulates in Snapping Turtle (Chelydra serpentina) Liver Activating the Detoxification Pathway.

Colson, Tash-Lynn L.; De Solla, Shane R.; Balakrishnan, Vimal K.; Toito, John et Langlois, Valérie S. ORCID: https://orcid.org/0000-0003-4031-6838 (2020). N-phenyl-1-naphthylamine (PNA) Accumulates in Snapping Turtle (Chelydra serpentina) Liver Activating the Detoxification Pathway. Bulletin of Environmental Contamination and Toxicology , vol. 105 , nº 6. pp. 813-818. DOI: 10.1007/s00128-020-03043-0.

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Résumé

Substituted phenylamine antioxidants (SPAs) are used in Canadian industrial processes. SPAs, specifically N-phenyl-1-naphthylamine (PNA), have received very little attention despite their current use in Canada and their expected aquatic and environmental releases. There is a research gap regarding the effects of PNA in wildlife; therefore, Chelydra serpentina (common snapping turtle) was studied due to its importance as an environmental indicator species. A chronic experiment was performed using PNA spiked food (0 to 3446 ng/g) to determine its toxicity to juvenile C. serpentina. A significant increase in cyp1a mRNA level was observed in the liver of turtles exposed to 3446 ng/g PNA, suggesting that phase I detoxification is activated in the exposed animals. Additionally, a significant decrease in cyp2b transcript level was observed at the two lowest PNA doses, likely indicating another metabolic alteration for PNA. This study helped determine the molecular effects associated with a PNA exposure in reptiles.

Type de document:	Article
Mots-clés libres:	cytochrome P450; metabolism; N-phenyl-1-naphthylamine;toxicity; turtle
Centre:	Centre Eau Terre Environnement
Date de dépôt:	09 juin 2021 15:37
Dernière modification:	10 févr. 2022 21:26
URI:	https://espace.inrs.ca/id/eprint/11474

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