Dlim, Marwa; Shahout, Fatma; Khabir, Marwa; Labonté, Patrick; Laplante, Steven
(2019).
Revealing Drug Self-Associations into Nano-Entities
ACS Omega
, vol. 4
, nº 5.
p. 8919-8925.
DOI: 10.1021/acsomega.9b00667.
Résumé
The aqueous properties of the drugs Sorafenib, Lapatinib, Gefitinib, Fulvestrant, and Clofazimine were explored to monitor their tendency to self-associate. A combination of nuclear magnetic resonance, dynamics light scattering, and electron and confocal microscopies found that they tended to form large nano-entities having distinct types and sizes and were capable of entering cells. The combination of strategies employed serves to detect and reveal nano-entities along with their three-state equilibria and behaviors in buffers, media, and cells.
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