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Clinical trial of live attenuated rubella virus vaccine hpv-77 strain

Pavilanis, Vytautas; Chagnon, André; Davignon, Lise; Joncas, Jean (1969). Clinical trial of live attenuated rubella virus vaccine hpv-77 strain In: International Symposium on Rubella Vaccines, 1968, London, England.

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Résumé

The high passage experimental live rubella virus, HPV-77, was inoculated to 24 institutionalized infants 5 to 12 months old; among them, 19 had no detectable antibody and 5 had hemagglutination-inhibiting (HI) antibodies at low levels before vaccination. The vaccins was immunogenic in 16 (84.2%) of the 19 susceptible infants. Out of the 5 seropositive infants 5 month old, an age at which maternal antibodies may be present, one showed an increase of antibody titre. There were no symptoms observed which could be attributed to the vaccine. Depiste pharyngeal shedding of virus in 20% of the vaccinated infants, there was no spread of infection to 16 control infants who lived in the siolation unit in intimate, continous contact with the vaccinated infants. Among the controls, 12 susceptible infants were still seronegative after 70 days following inoculation and 4, who had maternal HI antibodies, showed a progressive decrease of antibody titres and all were seronegative 70 days postvaccination.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Recueil de tiré-à-part de la bibliothèque: A0420 Symposium Series on Immunobiology Standardization, 11, pp.301-314
Mots-clés libres: hpv-77; rubella; rubeole; vaccin; virus
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 28 janv. 2020 20:37
Dernière modification: 28 janv. 2020 20:37
URI: http://espace.inrs.ca/id/eprint/8468

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