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Tuberculosis and thyroid function : I- metabolic cycle of radioiodine in bcg - inoculated guinea-pigs

Sternberg, Joseph; Frappier, Armand (1954). Tuberculosis and thyroid function : I- metabolic cycle of radioiodine in bcg - inoculated guinea-pigs Revue canadienne de biologie , vol. 13 , nº 5. p. 499.

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Résumé

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The modification of thyroid function in tuberculous infection has been noted long ago in clinical observations. The general impression was that a hyperfunctional gland offered a better protection for the tubercular infection. Experimental data confirmed the correlation between the gland and the resistance towards infection.

The recent advances in thyroid physiology realized with 1131 offered a new way to approach the problem. We have started the study with the new investigation of the functional modifications in thyroid by B.C.G. vaccinated animals. Thirty guinea pigs, at the supposed peak of their resistance - three months after a BCG vaccination - were injected with - three months after a BCG vaccination - were injected with mineral radioiodine and killed 48 and 96 hours later. The urinary and faecal elimination, the thyroid uptake and the fixation in various organs were measured and compared to thart of 30 identically treated control animals.

There is a significant increase in 1131 concentration in the thyroid of vaccinated animals as compared to that of controls; the ratio vaccinated/controls averages 150%. However, the absolute thyroid uptake does not show the same variations. The urinary elimination of radioiodine reflects the thyroid fixation and is diminished in vaccinated animals, especially towards the fourth day after injection (46% of the control). There is no significant increasse in (serum) PBI of vaccinated animals. Among other organs, it is to be noted an important increase of radioiodine fixation in the adrenals of vaccinated animals (340%).

Type de document: Article
Mots-clés libres: bcg; cycle; fonction; function; guinea-pig; hamster; metabolic; radioiodine; thyroid; tuberculosis
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 07 févr. 2020 15:45
Dernière modification: 07 févr. 2020 15:45
URI: http://espace.inrs.ca/id/eprint/8315

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