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Characterization of PMMA-b-PDMAEMA aggregates in aqueous solutions

Saraiva, Greice Kelle Viegas; de Souza, Valdomiro Vagner; de Olivieira, Luciana Coutinho; Noronha, Maria Luiza de Carvalho; Masini, Jorge César; Chaimovich, Hernan; Salinas, Roberto Kopke; Florenzano, Fábio Herbst; Cuccovia, Iolanda Midea (2019). Characterization of PMMA-b-PDMAEMA aggregates in aqueous solutions Colloid and Polymer Science , vol. 297 , nº 4. p. 557-569. DOI: 10.1007/s00396-019-04482-w.

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Résumé

Diblock amphiphilic copolymers form aggregates in some solvents. Such aggregates exhibit different morphologies, depending mainly on the polar/apolar block ratios. Aggregation of copolymers with polar block excess leads to micelle-like aggregates, known as polymeric micelles, which can be used as vehicles for drug and gene delivery, water decontamination, and catalysis. Here, we synthesized by RAFT polymerization three different polymers namely [dimethyl 2-(aminoethyl) methacrylate] (PDMAEMA), poly (methyl methacrylate) (PMMA) copolymers, and PDMAEMA-block-PMMA and characterized their aggregates by NMR spectroscopy and pH titrations. We investigated correlations between their chemical structure, aggregation behavior, protonation degree, and chain conformation in the corona. Decreased amine protonation in the copolymers reduced the electrostatic repulsion, and the apparent pKa of the amino groups approached that of isolated amine. These effects increased compactness and sizes of the polymers and their aggregates at higher pH as reflected by the increased NMR line widths.

Type de document: Article
Mots-clés libres: Copolymers, Polymer solutions, Polymer synthesis, Responsive systems, Spectroscopy, Magnetic resonance: NMR/ESR
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 05 févr. 2020 21:41
Dernière modification: 05 févr. 2020 21:41
URI: http://espace.inrs.ca/id/eprint/8213

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