Parent, Marie-Élise; Demoury, Claire; Cutumisu, Nicoleta; Barnett, Tracie A; Robitaille, Éric; Sigler, Brittany et Richard, Hugues . Neighbourhood Social and Material Deprivation and Prostate Cancer Risk in Montreal. Canada In: Society for Epidemiological Research’s 2016 Epidemiology Congress of the Americas, 21-24 Juin 2016, Miami.
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Introduction: Pr ostate cancer (PCa) r isk shows str ong spatial var iation which remains largely unexplained. We describe PCa risks in relation to neigh- bourhood social and material census - derived deprivation. Methods: In a case - control study in Montreal, 1,933 incident PCa cases aged ≤75 years were ascer- tained across French hospitals in 2005 - 9, and 1,994 age - matched (±5 years) controls were selected from electoral lists. Interviews elicited sociodemographic and lifestyle characteristics. Addresses at diagnosis (cases) or recruitment (controls) were geocoded and linked to two census - derived indices of material (income, education, employment) and social (proportion of people living alone, separated or widow, and single - parent families) deprivation in dissemination areas (census areas inhabited by 400 - 700 persons).Results: Polytomous lo- gistic regression was used to estimate ORs (95% confidence intervals [CI]) for the association between the two indices, in quintiles, and risk of low - and high - grade (Gleason score of 7 [4+3] or higher) PCa. Models were adjusted for age, ancestry, 1st degree family history, education, income, marital status, physical activity, BMI, frequency of physician visits, exposure to traffic - related air pol- lution, and PCa screening frequency. For material deprivation, using the most favourable quintile as referent, the OR for low - grade PCa across increasingly unfavourable quintiles were 1.07, 1.25, 1.11, 1.05; for high - grade PCa, corre- sponding values were 1.15, 1.48, 1.25, 1.39, none reaching significance. For social deprivation, ORs for low - grade PCa were 0.70, 1.32, 1.16, 1.50, while for high - grade PCa, they were 1.38 (95%CI 0.79 - 2.43), 1.34 (0.78 - 2.32), 1.85 (1.13 - 3.03), and 2.04 (1.23 - 3.38). Discussion: Low - grade PCa showed little association with neighbourhood material or social deprivation. High-gradePCawas weakly associated with material deprivation but it was strongly associated with social deprivation, independently of individual factors.
| Type de document: | Document issu d'une conférence ou d'un atelier |
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| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 25 juin 2018 15:37 |
| Dernière modification: | 16 juin 2023 16:02 |
| URI: | https://espace.inrs.ca/id/eprint/5765 |
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