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Label-free cocaine aptasensor based on a long-period fiber grating

Celebanska, Anna; Chiniforooshan, Yasser; Janik, Monika; Mikulic, Predrag; Sellamuthu, Balasubramanian; Walsh, Ryan; Perreault, Jonathan; Bock, Wojtek J. (2019). Label-free cocaine aptasensor based on a long-period fiber grating Optics Letters , vol. 44 , nº 10. p. 2482-2485. DOI: 10.1364/OL.44.002482.

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Résumé

In this Letter, we combined a promising bioreceptor, a cocaine aptamer MN6, with an ultrasensitive optical platform long-period fiber grating (LPFG) to create a new cocaine biosensor. The cocaine induces a conformational rearrangement of the aptamer which changes the refractive index around the LPFG producing a measurable shift of the transmission spectrum. We were able to track subtle interaction between the receptor and cocaine molecules over a concentration range of 25 to 100 μM. The presented biosensor does not require labeling or signal enhancement, resulting in a simple user-friendly device.

Type de document: Article
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 11 janv. 2020 15:38
Dernière modification: 11 janv. 2020 15:38
URI: http://espace.inrs.ca/id/eprint/8602

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