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How Prenatal Maternal Exposure to a Stressor Can Alter Placental Functions: The Role on Fetal Immune System Programming

Vaillancourt, Cathy (2019). How Prenatal Maternal Exposure to a Stressor Can Alter Placental Functions: The Role on Fetal Immune System Programming In: 59th Annual Teratology Society Meeting : Sea Changes in Birth Defects Research and Prevention, June 23-26 2019, San Diego, Californiia.

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Résumé

In utero exposure to maternal environmental stressors such as prenatal stress, depression, pharmaceutical drugs, and contaminants might affect placental function, which may have short- and long-term consequences on the development and programming of the fetus immune system. Exposure to environmental stressors during pregnancy is inevitable, thus it is crucial to develop new in vitro, ex vivo, and in vivo approach to determine the potential teratogenicity of environmental stressor, which may have short- and long-term consequences on the development and programming of the fetus. This talk will discuss how the effect of placental alterations by maternal exposure to stressor can affect fetal development and programming and present new approaches to model placental-fetal exposure to maternal stressor in vitro and in vivo. The importance of fetal sex variable in the effect of maternal exposure to stressors on placental function and fetal programming will also be discussed. This talk will also provide an overview about the protective effects of melatonin during pregnancy and on fetal development and programming. A better understanding of the effect of exposure of maternal environmental stressors placental function, according to fetal sex, could lead to finding early biomarkers of immune diseases programmed in utero.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Birth Defects Research (111), p.456, DOI:10.1002/bdr2.1515
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 11 déc. 2019 21:29
Dernière modification: 11 déc. 2019 21:29
URI: http://espace.inrs.ca/id/eprint/8597

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