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Reactogenicity serologic response to trivalent inactivated A-Texas, A-USSR and B-Hong-Kong whole-virus influenza vaccine in human volunteers

Lavergne, Berthe; Frappier-Davignon, Lise; Chagnon, André; Burr-Paxton, Mary; Quevillon, Marc; Pavilanis, Vytautas; Beaulnes, Auréle (1980). Reactogenicity serologic response to trivalent inactivated A-Texas, A-USSR and B-Hong-Kong whole-virus influenza vaccine in human volunteers Canadian Journal of Public Health , vol. 71 , nº 1. p. 25-31.

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Résumé

Responses to dose of 100 and 200 CCA units of a trivalent A/texas, A/USSR, and B/Hong Kong inactivated whole-virus vaccine produced by the Institut Armand-Frappier were evaluated in 667 adults volunteers in good health. No severe symptoms or clinical signs were observed. Temperature, mean systemic, reaction index and clinical signs in general were significantly higher among recipients of the larger dose of vaccine. No relationshop was noted between reactofenicity and serologic response. The presence of preexisting antibodies did not decrease the reactogenicity except in the case of A/USSR in the 26-50 age group. fourfold or greater increasees in titre occurred in nearly 100% of 249 seronegative recipients of A/Texas, irrespective of dose. Imn 274 seronegative recipients of A/USSR, such increases occured in 42% of those given 100 CCA units and in 67.8% in volunteers receiving 200 CCA units. In 230 seronegative recipients of B/Hong Kong, such increases occurred in 88.6% of those injected with 100 CCA units and 95.2% in those gfiven 200 CCA units. Seronegative subjects of 26 years of age and older had a better serologic response than those aged 18-25 with each dose of the A/USSR strain but there were no age differences in the response to the A/Texas and B/Hong Kong strains. The serologic response to 200 CCA units was significantly higher for the A/USSR strain in all age groups and for the B/Hong Kong strain in subjects aged 18-25.

Type de document: Article
Informations complémentaires: Recueil de tiré-à-part de la bibliothèque: A0969
Mots-clés libres: influenza; trivalent; vaccin
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 13 févr. 2020 15:08
Dernière modification: 13 févr. 2020 15:08
URI: http://espace.inrs.ca/id/eprint/8471

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