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Rubella antibody studies in the inhabitants of montreal : incidence of hemagglutination inhibiting complement fixing and neutralizing antibodies

Chagnon, André; Davignon, Lise; Pavilanis, Vytautas . Rubella antibody studies in the inhabitants of montreal : incidence of hemagglutination inhibiting complement fixing and neutralizing antibodies In: International Symposium on rubella Vaccines, 1968, London, England.

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Résumé

Sera from 690 individuals obtained between October 1966 to March 1968 and including infants, children, adults of both sexes and pregnant women, were tested for rubella antibodies. Seroimmunity was determined by hemagglutionation-inhibition (HI), complement-ficxation (CF) and neutralization (NT) of rubella virus. The age distribution of rubella antibidoes disclosed a pattern common the most viral infections which are acquired mainly during childhood and early adolescence and are followed by lifelong humoral immunity. Rubella HI and NT were found in 94.1% and 87.5% of the infants of 0 to 6 months old whereas only 30% showed CF activity. The presumably acquired maternal antibodies progressively decreased with age; among the children of 2 years old no antibody could be detected by the three serological methods. Rubella infection occured in a small proportion of children, 3 years of age, but not infection was acquired among those aged between 4 and 6 years. Fifty percent of school-age children, 6 to 10 years of age, acquired rubella infection. Then no infection occured among the children in the age group 11 to 12 years. Finally, 20% of the children aged between 13 and 14 years acquired rubella infection. Out of 468 adults, 16 years old and over including 413 pregnant women, 92.3% were seropositive by HI and NT whereas only 31.3% by CF.

The presence of HI and NT antibodies in 98.3% of institutionalized children, 13 to 36 months of age, following a known recent rubella infection confirmed the high susceptibility of that age group to infection. Comparative data obtained by NT and HI tests were in almost complete agreement. a small correlation was seen in titers at all levels of antibodies in general, HI titers were much higher. Hemagglutination-inhibition is a rapid serological method highly suitable for serological surveys of large groups providing a mean of determining the infection rate in various age groups.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Recueil de tiré-à-part de la bibliothèque: A0419 Symposium Series Immunobiologic Standardization, 11, pp.59-66
Mots-clés libres: antibody; anticorps; hemagglutination; montreal; rubella; rubeole; virus
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 28 janv. 2020 20:30
Dernière modification: 28 janv. 2020 20:30
URI: http://espace.inrs.ca/id/eprint/8463

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