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Serotonin-estrogen interactions: What can we learn from pregnancy?

Hudon-Thibeault, Andrée-Anne; Sanderson, J. Thomas; Vaillancourt, Cathy (2019). Serotonin-estrogen interactions: What can we learn from pregnancy? Biochimie , vol. 161 . p. 88-108. DOI: 10.1016/j.biochi.2019.03.023.

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Résumé

We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence is influenced by estrogenic status: depression, migraine, irritable bowel syndrome and eating disorders. These diseases all have in common a sex-dimorphic prevalence, with women more frequently affected than men. The co-occurrence between these 5-HT-linked diseases suggests that they have common physiopathological mechanisms. In most 5-HT-linked diseases (except for anorexia nervosa and irritable bowel syndrome), a decrease in the serotonergic tone is observed and estrogens are thought to contribute to the improvement of symptoms by stimulating the serotonergic system. Human pregnancy is characterized by a unique 5-HT and estrogen synthesis by the placenta. Pregnancy-specific disorders, such as hyperemesis gravidarum, gestational diabetes mellitus and pre-eclampsia, are associated with a hyperserotonergic state and decreased estrogen levels. Fetal programming of 5-HT-linked diseases is a complex phenomenon that involves notably fetal-sex differences, which suggest the implication of sex steroids. From a mechanistic point of view, we hypothesize that estrogens regulate the serotonergic system, resulting in a protective effect against 5-HT-linked diseases, but that, in turn, 5-HT affects estrogen synthesis in an attempt to retrieve homeostasis. These two processes (5-HT and estrogen biosynthesis) are crucial for successful pregnancy outcomes, and thus, a disruption of this 5-HT-estrogen relationship may explain pregnancy-specific pathologies or pregnancy complications associated with 5-HT-linked diseases.

Type de document: Article
Mots-clés libres: Depression; Eating disorders; Irritable bowel syndrome; Migraine; Pregnancy complications; Sex-dimorphism
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 22 nov. 2019 06:07
Dernière modification: 22 nov. 2019 06:07
URI: http://espace.inrs.ca/id/eprint/8204

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