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Biological activities of interleukin (IL)-21 in human monocytes and macrophages.

Vallières, Francis; Durocher, Isabelle; Girard, Denis (2019). Biological activities of interleukin (IL)-21 in human monocytes and macrophages. Cellular Immunology , vol. 337 . p. 62-70. DOI: 10.1016/j.cellimm.2019.02.002.

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Résumé

The biological roles of interleukin (IL)-21 in human monocytes and macrophages have been neglected. We previously demonstrated that IL-21 induce phagocytosis and established that Syk is a new molecular target of IL-21. Herein, we found that IL-21 is not chemoattractant for immature THP-1 and primary monocytes but can increase the capacity of THP-1 cells (not primary monocytes) to adhere onto a cell substratum by a Syk-dependent mechanism without altering the expression of a panel of cell surface molecules. Unlike THP- 1 and monocytes, IL-21 can increase metalloproteinase (MMP)-9 secretion and activity in monocyte-derived macrophages (HMDM), as assessed by western blot and zymography experiments, respectively. We reported that IL-21 did not increase the production of IL-6 and the chemokines MIP-1α and GRO-α in HMDM. Therefore, IL-21 can increase functions other that phagocytosis, but this cytokine does not have a large spectrum of biological activities in monocytes and macrophages.

Type de document: Article
Mots-clés libres: Cellular functions; Interleukin-21; Macrophages; Monocytes
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 20 nov. 2019 21:08
Dernière modification: 20 nov. 2019 21:08
URI: http://espace.inrs.ca/id/eprint/8184

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