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Occupational solvent exposure and risk of glioma in the INTEROCC study

Benke, Geza; Turner, Michelle C; Fleming, Sarah; Figuerola, Jordi; Kincl, Laurel; Richardson, Lesley; Blettner, Maria; Hours, Martine; Krewski, Daniel; McLean, David; Parent, Marie-Élise; Sadetzki, Siegal; Schlaefer, Klaus; Schlehofer, Brigitte; Siemiatycki, Jack; Van Tongeren, Martie; Cardis, Elisabeth (2017). Occupational solvent exposure and risk of glioma in the INTEROCC study British Journal of Cancer , vol. 117 . p. 1246-1254. DOI: 10.1038/bjc.2017.285.

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Résumé

BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.

METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.

RESULTS: Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.

CONCLUSIONS: The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.

Type de document: Article
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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 10 mars 2019 19:32
Dernière modification: 10 mars 2019 19:32
URI: http://espace.inrs.ca/id/eprint/7533

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