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Early Life Exposeres and Risk of Asthma

Rousseau, Marie-Claude; Conus, Florence; Parent, Marie-Élise (2016). Early Life Exposeres and Risk of Asthma In: Society for Epidemiological Research’s 2016 Epidemiology Congress of the Americas, Juin 2016, Miami.

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Résumé

We aimed at identifying early life exposures associated with subsequent risk of asthma in a cohort of persons born in 1974 in the province of Quebec, Canada, and followed for asthma occurrence until 1994. This cohort was originally designed to study bacillus Calmette-Guerin (BCG) vaccination in relation to asthma. Using a two-stage sampling strategy with a balanced design according to BCG vaccination and asthma status, information was obtained from sociodemographic and health administrative databases (stage 1 sample, n=76,623) and telephone interviews conducted with a subset of subjects (stage 2 sample, n=1,643). Subjects were considered as having asthma if they had ≥2 physician claims or ≥1 hospitalization for asthma. The factors investigated were birth weight, gestational age, parents’ age at childbirth, number of older siblings, type of delivery, breastfeeding, daycare attendance, pet ownership, parental smoking during pregnancy and infancy, family history of asthma, parental education, and occurrence of whooping cough, mumps, measles, rubella, chickenpox or worm infections before age 6. Applying a backward elimination strategy, logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for factors related to asthma risk, adjusted for census-based income and rural/urban residence. Multiple imputations by the Markov Chain Monte Carlo method were used to handle missing values. Among the 1,643 stage 2 sample subjects, 58% were females and 51% had asthma. Early life exposures associated with asthma risk were number of older siblings (≥2 vs. 0; OR: 0.71, 95% CI: 0.54-0.94), as well as father’s (OR: 2.19, 95% CI: 1.53- 3.13), mother’s (OR: 1.98, 95% CI: 1.46-2.69), and siblings’ history of asthma (OR: 1.43, 95% CI: 1.11-1.84). Results did not differ by sex. In conclusion, among the early life exposures examined, familial composition and antecedents of asthma were the only ones associated with risk of asthma in our study population.

Type de document: Document issu d'une conférence ou d'un atelier
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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 14 sept. 2017 14:57
Dernière modification: 14 sept. 2017 14:57
URI: http://espace.inrs.ca/id/eprint/5868

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