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The Remodeling of the Cytoplasm by Dengue Virus

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Chatel-Chaix, Laurent (2016). The Remodeling of the Cytoplasm by Dengue Virus Journal of Bacteriology and Mycology , vol. 3 , nº 4:1039. p. 1-6.

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Résumé

Infection with Dengue Virus (DENV) causes the most prevalent arthropodborne viral disease worldwide. Since there are no antivirals available, there is an urgent medical need to discover novel therapeutic targets, implying a better understanding of the cellular and molecular events governing DENV life cycle. Following infection, DENV induces a massive remodeling of the cytoplasm including the endoplasmic reticulum from which DENV replication factories are formed. In addition, DENV alters the morphology of other organelles such as mitochondria to hijack their functions and to create a cellular environment favorable to viral replication. This review summarizes our current knowledge about the cytoplasmic remodeling activities of DENV.

Type de document: Article
Mots-clés libres: Dengue virus; Replication factories; Autophagy; Mitochondria; Innate immunity
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 26 févr. 2019 21:51
Dernière modification: 26 févr. 2019 21:51
URI: http://espace.inrs.ca/id/eprint/5824

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