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Neighbourhood Social and Material Deprivation and Prostate Cancer Risk in Montreal. Canada

Parent, Marie-Élise; Demoury, Claire; Cutumisu, Nicoleta; Barnett, Tracie A; Robitaille, Éric; Sigler, Brittany; Richard, Hugues . Neighbourhood Social and Material Deprivation and Prostate Cancer Risk in Montreal. Canada In: Society for Epidemiological Research’s 2016 Epidemiology Congress of the Americas, 21-24 Juin 2016, Miami.

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Résumé

Introduction: Pr ostate cancer (PCa) r isk shows str ong spatial var iation which remains largely unexplained. We describe PCa risks in relation to neigh- bourhood social and material census - derived deprivation.

Methods: In a case - control study in Montreal, 1,933 incident PCa cases aged ≤75 years were ascer- tained across French hospitals in 2005 - 9, and 1,994 age - matched (±5 years) controls were selected from electoral lists. Interviews elicited sociodemographic and lifestyle characteristics. Addresses at diagnosis (cases) or recruitment (controls) were geocoded and linked to two census - derived indices of material (income, education, employment) and social (proportion of people living alone, separated or widow, and single - parent families) deprivation in dissemination areas (census areas inhabited by 400 - 700 persons).

Results: Polytomous lo- gistic regression was used to estimate ORs (95% confidence intervals [CI]) for the association between the two indices, in quintiles, and risk of low - and high - grade (Gleason score of 7 [4+3] or higher) PCa. Models were adjusted for age, ancestry, 1st degree family history, education, income, marital status, physical activity, BMI, frequency of physician visits, exposure to traffic - related air pol- lution, and PCa screening frequency. For material deprivation, using the most favourable quintile as referent, the OR for low - grade PCa across increasingly unfavourable quintiles were 1.07, 1.25, 1.11, 1.05; for high - grade PCa, corre- sponding values were 1.15, 1.48, 1.25, 1.39, none reaching significance. For social deprivation, ORs for low - grade PCa were 0.70, 1.32, 1.16, 1.50, while for high - grade PCa, they were 1.38 (95%CI 0.79 - 2.43), 1.34 (0.78 - 2.32), 1.85 (1.13 - 3.03), and 2.04 (1.23 - 3.38).

Discussion: Low - grade PCa showed little associ- a t i o n w i t h n e i g h b o u r h o o d m a t e r i a l o r s o c i a l d e p r i v a t i o n . H i g h - g r a d e P C a w a s weakly associated with material deprivation but it was strongly associated with social deprivation, independently of individual factors.

Type de document: Document issu d'une conférence ou d'un atelier
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 25 juin 2018 15:37
Dernière modification: 25 juin 2018 15:37
URI: http://espace.inrs.ca/id/eprint/5765

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