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Exploitation of the Host Cell Membrane Fusion Machinery by Leishmania Is Part of the Infection Process

Matte, Christine; Descoteaux, Albert (2016). Exploitation of the Host Cell Membrane Fusion Machinery by Leishmania Is Part of the Infection Process PLoS Pathogens , vol. 12 , nº 12. e1005962-1-7. DOI: 10.1371/journal.ppat.1005962.

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Résumé

Successful vacuolar pathogens have developed sophisticated strategies to hijack the endomem- brane system of host cells, sabotage their signal transduction pathways, and evade antimicro- bial responses. The protozoan parasite Leishmania , the causative agent of leishmaniases in humans, is particularly adept at transforming the macrophage into a hospitable host cell. Here, we describe how Leishmania promastigotes subvert the macrophage membrane fusion machinery to create an intracellular compartment favorable to the establishment of infection and to manipulate host immune responses

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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 25 juin 2017 18:19
Dernière modification: 25 juin 2017 18:19
URI: http://espace.inrs.ca/id/eprint/5554

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