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Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection

Daugan, Matthieu; Murira, Armstrong; Mindt, Barbara C; Germain, Amélie; Tarrab, Esther; Lapierre, Pascal; Fritz, Jorg; Lamarre, Alain (2016). Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection Frontiers in Immunology , vol. 7 , nº 564. DOI: 10.3389/fimmu.2016.00564.

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Résumé

Elicitation of type I interferon (IFN-I) has been shown to both enhance and impair cell-mediated immune responses in acute and persistent viral infections, respectively. Here, we show that, in addition to its effect on T cells, IFN-I drives impairment of specific antibody responses through interaction with B cells in the acute phase of lymphocytic choriomeningitis virus (LCMV) infection. This impairment was limited to the T cell-dependent B cell response and was associated with disruption of B cell follicles, development of hypergammaglobulinemia (HGG), and expansion of the T follicular helper cell population. Antigen-specific antibody responses were restored by ablation of IFN-I signaling through antibody-mediated IFN-I receptor blockade and B cell-specific IFN-I receptor knockout. Importantly, IFN-I receptor deficiency in B cells also accelerated the development of LCMV neutralizing antibodies and alleviated HGG. These results provide a potential therapeutic target toward efficient treatment measures that limit immunopathology in persistent viral infections.

Type de document:
Mots-clés libres: LCMV; antibody formation; immunopathology; interferon type I; neutralizing antibodies
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 25 juin 2017 13:43
Dernière modification: 25 juin 2017 13:43
URI: http://espace.inrs.ca/id/eprint/5493

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