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Encapsulation and release studies of strawberry polyphenols in biodegradable chitosan nanoformulation.

Pulicharla, Rama; Marques, Caroline; Das, Ratul Kumar; Rouissi, Tarek; Brar, Satinder Kaur (2016). Encapsulation and release studies of strawberry polyphenols in biodegradable chitosan nanoformulation. International Journal of Biological Macromolecules , vol. 88 . p. 171-178. DOI: 10.1016/j.ijbiomac.2016.03.036.

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Résumé

Polyphenols (negative groups) of strawberry extract interacts with positively protonated amino groups of chitosan which helps in maximum encapsulation. This approach can improve the bioavailability and sustained release of phytochemicals having lower bioavailability. The optimum mass ratio of chitosan-tripolyphosphate and polyphenols (PPs) loading was investigated to be 3:1 and 0.5 mg/ml of strawberry extract, respectively. Prepared nanoformulation were characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy and scanning electron microscopy. The formed particles size ranged between 300 and 600 nm and polydispersity index (PDI) of ≈ 0.5. The optimized formulation showed encapsulation efficiency of 58.09% at 36.47% of polyphenols loading. Initial burst and continuous release of PPs was observed at pH 7.4 of in vitro release studies. PPs release profile at this pH was found to be non-Fickian analomous diffusion and the release was followed first order kinetics. And at pH 1.4, diffusion-controlled Fickian release of PPs was observed.

Type de document:
Mots-clés libres: strawberry fruits; polyphenols; chitosan; nanoformulation; controlled release
Centre: Centre Eau Terre Environnement
Date de dépôt: 20 déc. 2016 16:21
Dernière modification: 20 déc. 2016 16:21
URI: http://espace.inrs.ca/id/eprint/4009

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