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Leishmania and the macrophage: a multifaceted interaction

Podinovskaia, Maria; Descoteaux, Albert (2015). Leishmania and the macrophage: a multifaceted interaction Future Microbiology , vol. 10 , nº 1. p. 111-29. DOI: 10.2217/fmb.14.103.

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Résumé

Leishmania, the causative agent of leishmaniases, is an intracellular parasite of macrophages, transmitted to humans via the bite of its sand fly vector. This protozoan organism has evolved strategies for efficient uptake into macrophages and is able to regulate phagosome maturation in order to make the phagosome more hospitable for parasite growth and to avoid destruction. As a result, macrophage defenses such as oxidative damage, antigen presentation, immune activation and apoptosis are compromised whereas nutrient availability is improved. Many Leishmania survival factors are involved in shaping the phagosome and reprogramming the macrophage to promote infection. This review details the complexity of the host-parasite interactions and summarizes our latest understanding of key events that make Leishmania such a successful intracellular parasite.

Type de document:
Mots-clés libres: GP63; Leishmania; lipophosphoglycan; macrophage; phagocytosis; phagosome
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 10 mai 2017 20:07
Dernière modification: 10 mai 2017 20:07
URI: http://espace.inrs.ca/id/eprint/3243

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