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Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway

Chen, Meihui; Tan, Min; Jing, Minghua; Liu, Anmin; Liu, Qinyu; Wen, Shijun; Chen, Ziwei; Chao, Xiaojuan; He, Xixin; Ramassamy, Charles; Gao, Youheng; Pi, Rongbiao (2015). Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway Metabolic Brain Disease , vol. 30 , nº 1. p. 137-42. DOI: 10.1007/s11011-014-9580-x.

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Résumé

Berberine (BBR), one of the major constituents of Chinese herb Rhizoma coptidis, has been reported to exert beneficial effects to various diseases, including Alzheimer's disease (AD). In the present work, we aimed to investigate the effects of BBR on neuronal cell death induced by homocysteic acid (HCA), which was considered as a risk of AD. BBR significantly reduced HCA-induced reactive oxygen species (ROS) generation, lactate dehydrogenase release and subsequent cell death. LY294002, the PI3K inhibitor, blocked the protection as well as the up-regulation of Akt phosphorylation of BBR. Taken together, our results indicate that BBR protects HCA-induced HT-22 cell death partly via modulating Akt pathway, suggesting BBR may be a promising therapeutic agent for the treatment of HCA-related diseases, including AD.

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Mots-clés libres: Berberine ; Alzheimer’s disease ; Homocysteic acid ; Cytotoxicity ; Akt
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 29 mai 2017 15:55
Dernière modification: 29 mai 2017 16:01
URI: http://espace.inrs.ca/id/eprint/3162

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