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Traffic-related air pollution and prostate cancer risk: a case-control study in Montreal, Canada

Parent, Marie-Élise; Goldberg, Mark S; Crouse, Dan L; Ross, Nancy A; Chen, Hong; Valois, Marie-France; Liautaud, Alexandre (2013). Traffic-related air pollution and prostate cancer risk: a case-control study in Montreal, Canada Occupational and Environmental Medicine , vol. 70 , nº 7. p. 511-8. DOI: 10.1136/oemed-2012-101211.

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Résumé

OBJECTIVES: There is a paucity of information on environmental risk factors for prostate cancer. We conducted a case-control study in Montreal to estimate associations with exposure to ground-level nitrogen dioxide (NO2), a marker for traffic-related air pollution. METHODS: Cases were 803 men with incident prostate cancer, ≤ 75 years of age, and diagnosed across all French hospitals in Montreal. Concurrently, 969 controls were drawn from electoral lists of French-speaking individuals residing in the same electoral districts as the cases and frequency-matched by age. Concentrations of NO2 were measured across Montreal in 2005-2006. We developed a land use regression model to predict concentrations of NO2 across Montreal for 2006. These estimates were back-extrapolated to 1996. Estimates were linked to residential addresses at the time of diagnosis or interview. Unconditional logistic regression was used, adjusting for potential confounding variables. RESULTS: For each increase of 5 parts per billion of NO2, as estimated from the original land use regression model in 2006, the OR5ppb adjusted for personal factors was 1.44 (95% CI 1.21 to 1.73). Adding in contextual factors attenuated the OR5ppb to 1.27 (95% CI 1.03 to 1.58). One method for back-extrapolating concentrations of NO2 to 1996 (about 10 years before the index date) gave the following OR5ppb: 1.41 (95% CI 1.24 to 1.62) when personal factors were included, and 1.30 (95% CI 1.11 to 1.52) when contextual factors were added. CONCLUSIONS: Exposure to ambient concentrations of NO2 at the current address was associated with an increased risk of prostate cancer. This novel finding requires replication.

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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 29 mai 2017 18:55
Dernière modification: 29 mai 2017 18:55
URI: http://espace.inrs.ca/id/eprint/2955

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