Dépôt numérique

Gastrointestinal survival of bacteria in commercial probiotic products

Millette, Mathieu; Nguyen, Anne; Amine, Khalie Mahamad; Lacroix, Monique (2013). Gastrointestinal survival of bacteria in commercial probiotic products International Journal of Probiotics and Prebiotics , vol. 8 , nº 4. p. 149-156.

Ce document n'est pas hébergé sur EspaceINRS.


This work compared bacterial gastrointestinal (GI) resistance of commercial probiotic products (capsules, fermented milk and powder). To simulate GI transit, the probiotic products were subjected to gastric fluid for 120 min then to intestinal fluid for 180 min. Gastric and intestinal fluids were prepared according to United States Pharmacopeia protocols. Bacterial enumeration was compared before and after the GI transit to evaluate the protective effect of the vehicle or the food matrix. Bacteria of the four probiotic capsules covered with an enteric coating had a higher survival rate (>1 log10 CFU reduction) than uncoated. Eight encapsulated but non enteric coated probiotic products showed limited GI resistance (between 1 and 5 log10 CFU reduction) while five products showed no GI survival. For probiotic fermented milk, two products demonstrated excellent or good protective property (>1 log10 CFU reduction) while the other four showed no resistance. Only one of six powdered probiotic strains had excellent GI survival. This study demonstrated that GI survival varies from one probiotic product to another. It reiterates the importance of manufacturing probiotic strains using the appropriate vehicle for the bacteria to reach its site of action and produce the expected beneficial effects. Copyright © 2013 by New Century Health Publishers, LLC.

Type de document:
Mots-clés libres: Acid tolerance; Bile salts; Gastrointestinal; Probiotic
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 21 juin 2017 15:04
Dernière modification: 21 juin 2017 15:04
URI: http://espace.inrs.ca/id/eprint/2949

Actions (Identification requise)

Modifier la notice Modifier la notice