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Epigenetic regulation of mmp-9 gene expression

Labrie, Marilyne; St-Pierre, Yves (2013). Epigenetic regulation of mmp-9 gene expression Cellular and Molecular Life Sciences , vol. 70 , nº 17. p. 3109-3124. DOI: 10.1007/s00018-012-1214-z.

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Résumé

Matrix metalloproteinase 9 (MMP-9) is one of the most studied enzymes in cancer. MMP-9 can cleave proteins of the extracellular matrix and a large no. of receptors and growth factors. Accordingly, its expression must be tightly regulated to avoid excessive enzymic activity, which is assocd. with disease progression. Although we know that epigenetic mechanisms play a central role in controlling mmp-9 gene expression, predicting how epigenetic drugs could be used to suppress mmp-9 gene expression is not trivial because epigenetic drugs also regulate the expression of key proteins that can tip the balance towards activation or suppression of MMP-9. Here, we review how our understanding of the biol. and expression of MMP-9 could be exploited to augment clin. benefits, most notably in terms of the prevention and management of degenerative diseases and cancer. [on SciFinder(R)]

Type de document:
Mots-clés libres: MMP-9 Epigenetics DNA methylation Non-coding RNA Histone Cancer
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 19 juin 2017 20:26
Dernière modification: 19 juin 2017 20:26
URI: http://espace.inrs.ca/id/eprint/2929

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