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Rhamnolipids: Detection, Analysis, Biosynthesis, Genetic Regulation, and Bioengineering of Production

Abdel-Mawgoud, Ahmad Mohammad; Hausmann, Rudolf; Lépine, François; Müller, Markus M.; Déziel, Éric (2011). Rhamnolipids: Detection, Analysis, Biosynthesis, Genetic Regulation, and Bioengineering of Production In: Biosurfactants : From Genes to Applications. Microbiology Monographs (20). Springer, Berlin, p. 13-55.

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Résumé

As promising biotechnological products, rhamnolipids (RLs) are the most investigated biosurfactants. Over the years, important efforts have been spent and an array of techniques has been developed for the isolation of producing bacterial strains and the characterization of a large variety of RL homologs and congeners. Investigations on RL production by the best known producer, the opportunistic pathogen Pseudomonas aeruginosa, have shown that production of RLs proceeds through de novo biosynthesis of precursors. Over the last 15 years, the genetic details underlying RL production in P. aeruginosa have been mostly unraveled, revealing a complex regulatory mechanism controlled by quorum sensing pathways of intercellular communication. A number of nutritional and cultivation factors affecting RL productivity have also been identified, while the use of many affordable and renewable raw substrates has been described to optimize the production. Multidisciplinary approaches are increasingly adopted to develop methods for the safe, cost-effective, and highly efficient production of RLs at the industrial scale

Type de document:
Mots-clés libres: Pseudomonas aeruginosa
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 30 avr. 2014 15:05
Dernière modification: 20 mars 2015 15:52
URI: http://espace.inrs.ca/id/eprint/2204

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