Document quand l'auteur est "Ayotte, Yann"

Mistretta, Maxime; Cimino, Mena; Campagne, Pascal; Volant, Steven; Kornobis, Etienne; Hebert, Olivier; Rochais, Christopher; Dallemagne, Patrick; Lecoutey, Cédric; Tisnerat, Camille; Lepailleur, Alban; Ayotte, Yann; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Gangneux, Nicolas; Záhorszká, Monika; Korduláková, Jana; Vichier-Guerre, Sophie; Bonhomme, Frédéric; Pokorny, Laura; Albert, Marvin; Tinevez, Jean-Yves et Manina, Giulia (2024). Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy Nature Communications , vol. 15 , nº 4175. pp. 1-22. DOI: 10.1038/s41467-024-48269-2.

Boulon, Richard; Mazeaud, Clément; Farahani, Majid D; Broquière, Mathilde; Iddir, Mustapha; Charpentier, Tania; Anton, Anaïs; Ayotte, Yann; Woo, Simon; Lamarre, Alain ORCID: https://orcid.org/0000-0002-7913-871X; Chatel-Chaix, Laurent ORCID: https://orcid.org/0000-0002-7390-8250 et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2024). Repurposing Drugs and Synergistic Combinations as Potential Therapies for Inhibiting SARS-CoV-2 and Coronavirus Replication Acs Pharmacology & Translational Science , vol. ahead . DOI: 10.1021/acsptsci.4c00512.

Bendahan, David; Franca, Tanos Celmar Costa; Amiens, Kathleen C; Ayotte, Yann; Forgione, Pat et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2024). Synthesis of a thiophene-based fluorinated library applied to fragment-based drug discovery via ¹⁹F NMR with confirmed binding to mutant HRAS ^G12V New Journal of Chemistry , vol. ahead . (Sous Presse)

Ayotte, Yann (2023). Implementing methods and processes to support fragment-based drug discovery initiatives Thèse. Québec, Université du Québec, Institut national de la recherche scientifique, Doctorat en innovation pharmaceutique, 300 p.

Sow, Aïssatou Aïcha; Pahmeier, Felix; Ayotte, Yann; Anton, Anaïs; Mazeaud, Clément; Charpentier, Tania; Angelo, Léna; Woo, Simon; Cerikan, Berati; Falzarano, Darryl; Abrahamyan, Levon; Lamarre, Alain ORCID: https://orcid.org/0000-0002-7913-871X; Labonté, Patrick ORCID: https://orcid.org/0000-0001-7262-3125; Cortese, Mirko; Bartenschlager, Ralf; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 et Chatel-Chaix, Laurent ORCID: https://orcid.org/0000-0002-7390-8250 (2023). N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle Antimicrobial Agents and Chemotherapy , vol. 67 , nº 2. pp. 1-14. DOI: 10.1128/aac.01331-22.

Larda, Sacha T; Ayotte, Yann; Denk, Maria M; Coote, Paul; Heffron, Gregory; Bendahan, David; Shahout, Fatma; Girard, Nicolas; Iddir, Mustapha; Bouchard, Patricia; Bilodeau, François; Woo, Simon; Farmer, Luc J et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2023). Robust Strategy for Hit-to-Lead Discovery: NMR for SAR Journal of medicinal chemistry , vol. 66 , nº 19. pp. 13416-13427. DOI: 10.1021/acs.jmedchem.3c00656.

Farahani, Majid D; Franca, Tanos Celmar Costa; Alapour, Saba; Shahout, Fatma; Boulon, Richard; Iddir, Mustapha; Maddalena, Michael et Ayotte, Yann (2022). Jumping from Fragment to Drug via Smart Scaffolds ChemMedChem , vol. 17 , nº 10. pp. 1-8. DOI: 10.1002/cmdc.202200092.

Farahani, Majid D; Franca, Tanos Celmar Costa; Alapour, Saba; Shahout, Fatma; Boulon, Richard; Iddir, Mustapha; Maddalena, Michael; Ayotte, Yann et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2022). Jumping From Fragment To Drug Via Smart Scaffolds ChemMedChem , vol. 17 , nº 10:e2022. pp. 1-8. DOI: 10.1002/cmdc.202200092.

Ayotte, Yann; Woo, Simon et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2022). Practical Considerations and Guidelines for Spectral Referencing for Fluorine NMR Ligand Screening ACS Omega , vol. 7 , nº 15. pp. 13155-13163. DOI: 10.1021/acsomega.2c00613.

Ayotte, Yann; Bernet, Eve; Bilodeau, François; Cimino, Mena; Gagnon, Dominic; Lebughe, Marthe; Mistretta, Maxime; Ogadinma, Paul; Ouali, Sarah-Lisa; Sow, Aïssatou Aïcha; Chatel-Chaix, Laurent ORCID: https://orcid.org/0000-0002-7390-8250; Descoteaux, Albert ORCID: https://orcid.org/0000-0002-0633-5309; Manina, Giulia; Richard, Dave; Veyrier, Frédéric ORCID: https://orcid.org/0000-0002-8574-0547 et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2021). Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases ACS Chemical Biology , vol. 16 , nº 11. pp. 2158-2163. DOI: 10.1021/acschembio.1c00657.

Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Roux, Valérie; Shahout, Fatma; LaPlante, Gabriela; Woo, Simon; Denk, Maria M; Larda, Sacha et Ayotte, Yann (2021). Probing the free-state solution behavior of drugs and their tendencies to self-aggregate into nano-entities Nature Protocols , vol. 16 , nº 11. pp. 5250-5273. DOI: 10.1038/s41596-021-00612-3.

Ayotte, Yann; Marando, Victoria; Vaillancourt, Louis; Bouchard, Patricia; Heffron, Gregory; Coote, Paul W.; Larda, Sacha et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2019). Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay Journal of medicinal chemistry , vol. 62 , nº 17. pp. 7885-7896. DOI: 10.1021/acs.jmedchem.9b00653.

Ayotte, Yann; Murugesan, Jayadeepa R.; Bilodeau, François; Larda, Sacha; Bouchard, Patricia; Drouin, Nathalie; Morin, Melissa et Laplante, Steven (2017). Discovering Quality Drug Seeds by Practical NMR-based Fragment Screening In: 31st Annual Symposium of the Protein-Society, July 24-27, 2017, Montréal (Québec) Canada.

Ayotte, Yann; Murugesan, Jayadeepa R.; Fortier, Marlène; St-Pierre, Yves et Laplante, Steven . Criblage de fragments par RMN afin de découvrir des molécules ciblant la galectine-7 In: Congrès Armand-Frappier 2017 (10e édition), 9-11 novembre 2017, Orford (Québec).

Ayotte, Yann; Descoteaux, Albert et Laplante, Steven . Discovering the seeds for new drugs that target the neglected tropical disease leishmaniasis In: 16e symposium annuel de parasitologie moléculaire du Québec, 6-7 juin 2016, Université McGill, Montréal, QC.