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Revealing Drug Self-Associations into Nano-Entities

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Dlim, Marwa, Shahout, Fatma, Khabir, Marwa, Labonté, Patrick ORCID: https://orcid.org/0000-0001-7262-3125 et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2019). Revealing Drug Self-Associations into Nano-Entities ACS Omega , vol. 4 , nº 5. p. 8919-8925. DOI: 10.1021/acsomega.9b00667.

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Résumé

The aqueous properties of the drugs Sorafenib, Lapatinib, Gefitinib, Fulvestrant, and Clofazimine were explored to monitor their tendency to self-associate. A combination of nuclear magnetic resonance, dynamics light scattering, and electron and confocal microscopies found that they tended to form large nano-entities having distinct types and sizes and were capable of entering cells. The combination of strategies employed serves to detect and reveal nano-entities along with their three-state equilibria and behaviors in buffers, media, and cells.

Type de document: Article
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 20 nov. 2019 16:03
Dernière modification: 15 févr. 2022 18:47
URI: https://espace.inrs.ca/id/eprint/8606

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