Revealing Drug Self-Associations into Nano-Entities

Dlim, Marwa; Shahout, Fatma; Khabir, Marwa; Labonté, Patrick ORCID: https://orcid.org/0000-0001-7262-3125 et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2019). Revealing Drug Self-Associations into Nano-Entities ACS Omega , vol. 4 , nº 5. pp. 8919-8925. DOI: 10.1021/acsomega.9b00667.

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Résumé

The aqueous properties of the drugs Sorafenib, Lapatinib, Gefitinib, Fulvestrant, and Clofazimine were explored to monitor their tendency to self-associate. A combination of nuclear magnetic resonance, dynamics light scattering, and electron and confocal microscopies found that they tended to form large nano-entities having distinct types and sizes and were capable of entering cells. The combination of strategies employed serves to detect and reveal nano-entities along with their three-state equilibria and behaviors in buffers, media, and cells.

Type de document:	Article
Mots-clés libres:	-
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	20 nov. 2019 16:03
Dernière modification:	15 févr. 2022 18:47
URI:	https://espace.inrs.ca/id/eprint/8606

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