Celebanska, Anna; Chiniforooshan, Yasser; Janik, Monika; Mikulic, Predrag; Sellamuthu, Balasubramanian; Walsh, Ryan; Perreault, Jonathan 
ORCID: https://orcid.org/0000-0003-4726-6319 et Bock, Wojtek J.
(2019).
Label-free cocaine aptasensor based on a long-period fiber grating
Optics Letters
, vol. 44
, nº 10.
pp. 2482-2485.
DOI: 10.1364/OL.44.002482.
Résumé
In this Letter, we combined a promising bioreceptor, a cocaine aptamer MN6, with an ultrasensitive optical platform long-period fiber grating (LPFG) to create a new cocaine biosensor. The cocaine induces a conformational rearrangement of the aptamer which changes the refractive index around the LPFG producing a measurable shift of the transmission spectrum. We were able to track subtle interaction between the receptor and cocaine molecules over a concentration range of 25 to 100 μM. The presented biosensor does not require labeling or signal enhancement, resulting in a simple user-friendly device.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 11 janv. 2020 15:38 |
| Dernière modification: | 15 févr. 2022 21:07 |
| URI: | https://espace.inrs.ca/id/eprint/8602 |
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