Frappier, Armand et Guy, Roland (1950). A new and practical B.C.G. skin test (the B.C.G. scarification test) for the detection of the total tuberculous allergy Canadian Journal of Public Health , vol. 41 , nº 2. pp. 72-83.
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1. The authors describe and propose a new and pratical skin test, introducing B.C.G. by scarification, in order to detect the total tuberculous allergy; that is, allergy to tuberculin as well as allergy to bacillary proteins, or bodies, infratuberculin allergy as well as tuberculin allergy.
2. Of 626 individuals found negative to a strong dose of tuberculine (0.005 mg P.P.D.), 22.9 per cent were still positive to the B.C.G. scarification test, showing infratuberculin allergy, i.e. an accelerated reaction to B.C.G. and the Willis phenomenon (reduction of the pre-allergic period and enhancement of the reactivity to tuberculin). Similar findings were reported by few authors using intradermal or puncture tests.
3. It was found that the optimum live B.C.G. concentration for the test - that is, the concentration strong enough to show a reaction in the least sensitive individuals, including those infratuberculin allergic, but still unable to induce scar-forming reactions among strongly allergic subjects-is not less than 10 mg. per c.c. and not more than 25 mg. per c.c., preferably less.
4. The B.C.G. scarification test could be used for the following definite purposes: detection of intratuberculin allergy, epidemiological surveys of the distribution of tuberculous infection, and as an economical and efficient substitute for tuberculine test of an immediate B.C.G. vaccination.
| Type de document: | Article |
|---|---|
| Informations complémentaires: | Recueil de tiré-à-part de la bibliothèque: R071 |
| Mots-clés libres: | tuberculosis; tuberculose |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 10 févr. 2020 01:55 |
| Dernière modification: | 10 févr. 2020 01:55 |
| URI: | https://espace.inrs.ca/id/eprint/8410 |
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