Saint-Martin, Maurice; Sonea, Sorin; Desjardins, Roger et Frappier, Armand (1954). Studies on pathogenic staphylococcal infections. II. Incidence of penicillin-resistant strains in young healthy carriers and in clinical infections treated and not treated with penicillin Canadian Journal of Public Health , vol. 45 , nº 5. pp. 202-207.
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1. Penicillin-sensitivity tests, using a disk method, were done on 1,110 staphylococcal strains isolated from the naso-pharynx of the young healthy carriers. Similar tests were performed on 760 pathogenic staphylococci isolated from cases previously treated with penicillin and on 100 strains from cases not treated with this antibiotic. Testing of the last two categories for antibiotic sensitivity was done with dihydrostreptomycin, chloromycetin, aureomycin, terramycin and bacitracin.
2. Our results indicated that the majority of carrier strains (90.1%) are sensitive to penicillin, whereas the majority of strains isolated from treated cases (71.3%) and non-treated cases (58%) are penicillin-reistant.
3. Sensitivity tests done on strains from clinical cases, whether treated or not treated, did not show any statistical differences between the two categories, implying that probably half of present infections are due to cross-infection by resistant strains. Our data indicate that the degree of effectiveness of antibiotics used may be: first choice, chloromycetin, followed by aureomycin and terramycin; and as third choice, dihydrostreptmycin and penicillin. Limited studies done with erythromycin show that this antibiotic appears, for the time being, the most effective antibiotic. Bacitracin still remains the drug of choice for local treatment.
Type de document: | Article |
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Informations complémentaires: | Recueil de tiré-à-part de la bibliothèque: A0101a |
Mots-clés libres: | MICROCOCCAL INFECTIONS; PENICILLIN/effects; penicillin derivative; human; incidence; Micrococcus; pathogenicity; Staphylococcus infection; Humans; Penicillins; Staphylococcal Infections |
Centre: | Centre INRS-Institut Armand Frappier |
Date de dépôt: | 10 févr. 2020 02:05 |
Dernière modification: | 07 mai 2021 19:59 |
URI: | https://espace.inrs.ca/id/eprint/8401 |
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