Vallières, Francis; Durocher, Isabelle et Girard, Denis 
ORCID: https://orcid.org/0000-0002-3342-5027
(2019).
Biological activities of interleukin (IL)-21 in human monocytes and macrophages.
Cellular Immunology
, vol. 337
.
pp. 62-70.
DOI: 10.1016/j.cellimm.2019.02.002.
Résumé
The biological roles of interleukin (IL)-21 in human monocytes and macrophages have been neglected. We previously demonstrated that IL-21 induce phagocytosis and established that Syk is a new molecular target of IL-21. Herein, we found that IL-21 is not chemoattractant for immature THP-1 and primary monocytes but can increase the capacity of THP-1 cells (not primary monocytes) to adhere onto a cell substratum by a Syk-dependent mechanism without altering the expression of a panel of cell surface molecules. Unlike THP- 1 and monocytes, IL-21 can increase metalloproteinase (MMP)-9 secretion and activity in monocyte-derived macrophages (HMDM), as assessed by western blot and zymography experiments, respectively. We reported that IL-21 did not increase the production of IL-6 and the chemokines MIP-1α and GRO-α in HMDM. Therefore, IL-21 can increase functions other that phagocytosis, but this cytokine does not have a large spectrum of biological activities in monocytes and macrophages.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Cellular functions; Interleukin-21; Macrophages; Monocytes |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 20 nov. 2019 21:08 |
| Dernière modification: | 15 févr. 2022 17:34 |
| URI: | https://espace.inrs.ca/id/eprint/8184 |
Gestion Actions (Identification requise)
 |
Modifier la notice |