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Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus

Murthi, Padma et Vaillancourt, Cathy ORCID: https://orcid.org/0000-0003-0543-6244 (2019). Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease , vol. 1866 , nº 2. p. 1-8. DOI: 10.1016/j.bbadis.2019.01.017.

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Résumé

Serotonin (5-hydroxytryptamine, 5-HT) regulates diverse physiological and behavioural and processes, also acts as a developmental signal in early embryogenesis and in regulation of fetal development. A number of studies have implicated the prominent role of serotonin transporter (SERT or 5-HTT) and 5-HT receptor subtypes in placental development and function. Here, in this article we have provided a comprehensive review on the important role of 5-HT homeostasis in pregnancy outcomes. More specifically, we have summarised the findings from experimental and clinical studies, the influence of maternal and placental inflammation associated with the gestational diabetes and obesity on placental serotonin synthesis, expression of SERT and 5-HT receptors and their activity. Understanding the molecular regulation of placental SERT and 5-HT receptors using selective pharmacological agonists or antagonists may identify the therapeutic potential of serotonin pathway to improve long-term health outcomes of mothers and her infants exposed to GDM and obesity.

Type de document: Article
Informations complémentaires: This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). The publication was retracted by request of the authors following an investigation by Monash University performed following its Procedures for Investigating Code Breaches and in accordance with the Australian Code for the Responsible Conduct of Research. The University concluded on the balance of probability that a significant part of the text in the paper was included without knowledge, without consent and without correct attribution of the original author who, at the time, was a student at the University. The results discussed in the review article are still scientifically valid. ☆ This article is part of a Special Issue entitled: Membrane Transporters and Receptors in Pregnancy Metabolic Complications edited by Luis Sobrevia.
Mots-clés libres: Gestational diabetes mellitus; Inflammation; Obesity; Placenta; Pregnancy; Serotonin metabolic pathway
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 08 août 2019 01:32
Dernière modification: 16 févr. 2022 15:33
URI: https://espace.inrs.ca/id/eprint/8154

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