Dépôt numérique

Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol

Lalloz, Augustine, Bolzinger, Marie-Alexandrine, Faivre, Jimmy, Latreille, Pierre-Luc, Garcia Ac, Araceli, Rakotovao, Cyrielle, Hildgen, Patrice, Banquy, Xavier et Briançon, Stéphanie (2018). Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol International Journal of Pharmaceutics , vol. 553 , nº 1-2. p. 120-131. DOI: 10.1016/j.ijpharm.2018.09.046.

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We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile model drug. Poly(lactic acid) (PLA)-based NPs without surface coating, with a non-ionic poly(ethylene glycol) (PEG) coating, or with a zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) coating were prepared using flash nanoprecipitation. Process was optimized to obtain similar hydrodynamic diameters. Polymeric NPs were compared to non-polymeric cholecalciferol formulations. Cholecalciferol stability in aqueous medium was improved by polymeric encapsulation with a valuable effect of a hydrophilic coating. However, the in vitro release of the drug was found independent of the presence of any polymer, as for the drug penetration in an intact skin model. Such tendency was not observed in impaired skin since, when stratum corneum was removed, we found that a neutral hydrophilic coating around NPs reduced drug penetration compared to pure drug NPs and bare PLA NPs. The nature of the hydrophilic block (PEG or PMPC) had however no impact. We hypothesized that NPs surface influenced drug penetration in impaired skin due to different electrostatic interactions between NPs and charged skin components of viable skin layers.

Type de document: Article
Mots-clés libres: Cholecalciferol; Drug stability; Flash nanoprecipitation; Impaired skin; Nanoparticle surface; Skin penetration
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 08 août 2019 00:50
Dernière modification: 08 août 2019 00:50
URI: https://espace.inrs.ca/id/eprint/8136

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