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Prostate cancer in firefighting and police work: a systematic review and meta-analysis of epidemiologic studies


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Sritharan, Jeavana; Pahwa, Manisha; Demers, Paul; Harris, Shelley A; Cole, Donald C et Parent, Marie-Élise (2017). Prostate cancer in firefighting and police work: a systematic review and meta-analysis of epidemiologic studies Environmental Health , vol. 16 , nº 124. pp. 1-12. DOI: 10.1186/s12940-017-0336-z.

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OBJECTIVES: We conducted a systematic review and meta-analysis to evaluate potential associations between firefighting and police occupations, and prostate cancer incidence and mortality.

METHODS: Original epidemiological studies published from 1980 to 2017 were identified through PubMed and Web of Science. Studies were included if they contained specific job titles for ever/never firefighting and police work and associated prostate cancer risk estimates with 95% confidence intervals (CI). Study quality was assessed using a 20-point checklist. Prostate cancer meta-risk estimates (mRE) and corresponding 95% CIs were calculated for firefighting and police work separately and by various study characteristics using random effects models. Between-study heterogeneity was evaluated using the I2 score. Publication bias was assessed using Begg's and Egger's tests.

RESULTS: A total of 26 firefighter and 12 police studies were included in the meta-analysis, with quality assessment scores ranging from 7 to 19 points. For firefighter studies, the prostate cancer incidence mRE was 1.17 (95% CI = 1.08-1.28, I2 = 72%) and the mortality mRE was 1.12 (95% CI = 0.92-1.36, I2 = 50%). The mRE for police incidence studies was 1.14 (95% CI = 1.02-1.28; I2 = 33%); for mortality studies, the mRE was 1.08 (95% CI = 0.80-1.45; I2 = 0%). By study design, mREs for both firefighter and police studies were similar to estimates of incidence and mortality.

CONCLUSION: Small excess risks of prostate cancer were observed from firefighter studies with moderate to substantial heterogeneity and a relatively small number of police studies, respectively. There is a need for further studies to examine police occupations and to assess unique and shared exposures in firefighting and police work.

Type de document: Article
Mots-clés libres: Epidemiology; Firefighters; Incidence; Meta-analysis; Mortality; Occupation; Police; Prostate cancer risk; Systematic review
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 08 mars 2019 16:21
Dernière modification: 25 nov. 2020 18:48
URI: https://espace.inrs.ca/id/eprint/7537

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