Benke, Geza, Turner, Michelle C, Fleming, Sarah, Figuerola, Jordi, Kincl, Laurel, Richardson, Lesley, Blettner, Maria, Hours, Martine, Krewski, Daniel, McLean, David, Parent, Marie-Élise, Sadetzki, Siegal, Schlaefer, Klaus, Schlehofer, Brigitte, Siemiatycki, Jack, Van Tongeren, Martie et Cardis, Elisabeth (2017). Occupational solvent exposure and risk of glioma in the INTEROCC study British Journal of Cancer , vol. 117 . p. 1246-1254. DOI: 10.1038/bjc.2017.285.
Ce document n'est pas hébergé sur EspaceINRS.Résumé
BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.
METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.
RESULTS: Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.
CONCLUSIONS: The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 10 mars 2019 19:32 |
| Dernière modification: | 10 mars 2019 19:32 |
| URI: | https://espace.inrs.ca/id/eprint/7533 |
Actions (Identification requise)
 |
Modifier la notice |