Dépôt numérique

Dechlorane Plus induces oxidative stress and decreases cyclooxygenase activity in the blue mussel

Gagné, Pierre-Luc, Fortier, Marlène, Fraser, Marc, Parent, Lise, Vaillancourt, Cathy et Verreault, Jonathan (2017). Dechlorane Plus induces oxidative stress and decreases cyclooxygenase activity in the blue mussel Aquatic toxicology , vol. 188 . p. 26-32. DOI: 10.1016/j.aquatox.2017.04.009.

Ce document n'est pas hébergé sur EspaceINRS.


Dechlorane Plus (DP) is a chlorinated flame retardant used mainly in electrical wire and cable coating, computer connectors, and plastic roofing materials. Concentrations of DP (syn and anti isomers) are increasingly being reported in aquatic ecosystems worldwide. However, there is exceedingly little information on the exposure-related toxicity of DP in aquatic organisms, especially in bivalves. The objective of this study was to investigate the in vivo and in vitro effects of DP exposure on histopathology, lipid peroxidation (LPO) levels, cyclooxygenase (COX) activity, phagocytosis capacity and efficiency, and DNA strand breakage in the blue mussel (Mytilus edulis) following a 29days exposure (0.001, 0.01, 0.1 and 1.0mug DP/L). Blue mussels accumulated DP in muscle and digestive gland in a dose-dependent manner. LPO levels in gills were found to increase by 82% and 67% at the 0.01 and 1.0mug DP/L doses, respectively, while COX activity in gills decreased by 44% at the 1mug/L dose. No histopathological lesion was found in gonads following DP exposure. Moreover, no change in hemocyte DNA strand breakage, phagocytosis rate, and viability was observed following DP exposure. Present study showed that toxicity of DP may occur primarily via oxidative stress in the blue mussel and potentially other bivalves, and that gills represent the most responsive tissue to this exposure.

Type de document: Article
Mots-clés libres: Blue mussel; Cyclooxygenase; DNA damage; Dechlorane plus; Flame retardant; Lipid peroxidation
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 05 juill. 2017 15:20
Dernière modification: 13 avr. 2018 15:03
URI: https://espace.inrs.ca/id/eprint/5365

Actions (Identification requise)

Modifier la notice Modifier la notice