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Lung cancer risk among bricklayers in a pooled analysis of case-control studies


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Consonni, Dario; De Matteis, Sara; Pesatori, Angela Cecilia; Bertazzi, Pier Alberto; Olsson, Ann; Kromhout, Hans; Peters, Susan; Vermeulen, Roel; Pesch, Beate; Bruning, Thomas; Kendzia, Benjamin; Behrens, Thomas; Stucker, Isabelle; Guida, Florence; Wichmann, Heinz-Erich; Bruske, Irene; Landi, Maria Teresa; Caporaso, Neil; Gustavsson, Per; Plato, Nils; Tse, Lap Ah; Yu, Ignatius Tak-Sun; Jockel, Karl-Heinz; Ahrens, Wolfgang; Pohlabeln, Hermann; Merletti, Franco; Richiardi, Lorenzo; Simonato, Lorenzo; Forastiere, Francesco; Siemiatycki, Jack; Parent, Marie-Élise; Tardon, Adonina; Boffetta, Paolo; Zaridze, David; Chen, Ying; Field, John; t Mannetje, Andrea; Pearce, Neil; McLaughlin, John; Demers, Paul; Lissowska, Jolanta; Szeszenia-Dabrowska, Neonila; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Rudnai, Peter; Fabianova, Eleonora; Stanescu Dumitru, Rodica; Bueno-de-Mesquita, Bas; Schuz, Joachim et Straif, Kurt (2015). Lung cancer risk among bricklayers in a pooled analysis of case-control studies International Journal of Cancer , vol. 136 , nº 2. pp. 360-371. DOI: 10.1002/ijc.28986.

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Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control studies on lung cancer and the joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals (CI) adjusted for study center, age, lifetime smoking history and employment in occupations with exposures to known or suspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had ever worked as bricklayers (OR: 1.47; 95% CI: 1.28-1.68). In studies using population controls the OR was 1.55 (95% CI: 1.32-1.81, 540/349 cases/controls), while it was 1.24 (95% CI: 0.93-1.64, 155/120 cases/controls) in hospital-based studies. There was a clear positive trend with length of employment (p<0.001). The relative risk was higher for squamous (OR: 1.68, 95% CI: 1.42-1.98, 309 cases) and small cell carcinomas (OR: 1.78, 95% CI: 1.44-2.20, 140 cases), than for adenocarcinoma (OR: 1.17, 95% CI: 0.95-1.43, 150 cases) (p-homogeneity: 0.0007). ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents. This study provided robust evidence of increased lung cancer risk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in view of the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos. What's new? In their work, bricklayers can be exposed to various airborne carcinogens, including crystalline silica and asbestos. Previous studies of cancer risk have not accounted for full employment history or smoking status, and failed to establish a firm relationship between bricklaying and lung cancer. In this study, the authors used data from the largest collection of case-control studies on lung cancer with complete occupational and smoking history existing today, the SYNERGY project. They found clear evidence that lung cancer risk increases in proportion to the length of time spent working as a bricklayer, paving the way for better protection and compensation for those in this occupation.

Type de document: Article
Mots-clés libres: lung neoplasms; case-control studies; bricklayers; occupational health; epidemiology; crystalline silica dust; occupational-exposure; construction-industry; nordic countries; united-states; population; mortality; workers; men; carcinogens
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 26 mai 2017 15:44
Dernière modification: 10 mai 2021 19:12
URI: https://espace.inrs.ca/id/eprint/3165

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