Dépôt numérique


Vaudry, David, Nakamachi, Tomoya, Basille, Magali, Wurtz, Olivier, Fournier, Alain, Vaudry, Hubert et Shoida, Seiji (2013). PACAP In: Handbook of Biologically Active Peptides. Elsevier, Amsterdam, p. 889-897.

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Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 38- or 27-amino-acid peptide belonging to the VIP/secretin/GHRH/glucagon superfamily that was discovered from hypothalamic extracts for its ability to stimulate cAMP formation in anterior pituitary cells. PACAP and its 3 receptor subtypes are widely expressed in the brain, suggesting that this peptide may exert numerous functions in the central nervous system. In the developing brain, PACAP controls progenitor proliferation, migration, and differentiation. In the adult brain, PACAP regulates circadian rhythms, food intake, water drinking, locomotor activity, pain, and stress responses. PACAP is able to protect brain tissue from neurodegenerative diseases and stroke by inhibiting neuronal cell death and by stimulating neurogenesis. The diversity and complex effects of PACAP can be accounted for by the existence of at least 14 splice variants for the PACAP specific receptor, PAC1, which can modulate the coupling to various second messengers.

Type de document: Chapitre de livre
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 12 avr. 2017 16:21
Dernière modification: 12 avr. 2017 16:21
URI: https://espace.inrs.ca/id/eprint/2989

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