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Exposure to environmental tobacco smoke (ETS) and risk of lung cancer in Montreal: a case-control study


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Al-Zoughool, Mustafa; Pintos, Javier; Richardson, Lesley; Parent, Marie-Élise; Ghadirian, Parviz; Krewski, Daniel et Siemiatycki, Jack (2013). Exposure to environmental tobacco smoke (ETS) and risk of lung cancer in Montreal: a case-control study Environmental Health , vol. 12 . p. 112. DOI: 10.1186/1476-069X-12-112.

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BACKGROUND: The objective of the present study was to examine the association between environmental tobacco smoke (ETS) and risk of lung cancer among never smokers, defined as subjects who smoked less than 100 cigarettes in their lifetime. METHODS: We conducted a population-based case-control study on lung cancer in Montreal, Canada (1996-2000) including 1,203 cases and 1513 controls. The present analysis is restricted to the 44 cases and 436 population controls who reported never smoking and completed the questionnaire on lifetime ETS exposure. Collected information included duration and intensity of exposure from multiple sources: inside home (parents, spouses, roommates and any other co-resident) and outside homes (in vehicles, social settings, and workplace). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated between ETS and lung cancer, adjusting for age, sex, socioeconomic status (SES), and proxy respondent. RESULTS: Overall there was no association between ETS cumulative exposure from all sources (measured in pack-years) and lung cancer: OR = 0.98 (95%CI: 0.40-2.38), comparing upper with lower tertiles of exposure. While there were no elevated ORs associated with ever having lived with parents who smoked (OR = 0.62; 95%CI: 0.32-1.21) or with spouses who smoked (OR = 0.39; 95%CI: 0.18-0.85), ETS exposure from sources outside homes was associated with a slight, although non-significant increased risk: OR = 2.30 (95%CI: 0.85-6.19) for the upper 50% exposed. There were no clear differences in ORs by age at exposure to ETS or by histologic type of tumour, though numbers of subjects in subgroup analyses were too small to provide reliable estimates. CONCLUSION: No clear association between lifetime ETS exposure from all sources and increased risk of lung cancer was found in the current study.

Type de document: Article
Mots-clés libres: Environmental tobacco smoke, Lung cancer, Case–control study
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 22 mars 2016 20:37
Dernière modification: 11 janv. 2017 18:49
URI: https://espace.inrs.ca/id/eprint/2851

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