Morin-Genest, Julie et Girard, Denis 
ORCID: https://orcid.org/0000-0002-3342-5027
(2025).
Citrullinated vimentin and alpha enolase are expressed at the cell surface of apoptotic human neutrophils
Human Immunology
, vol. 87
, nº 111631.
pp. 1-5.
DOI: 10.1016/j.humimm.2025.111631.
Résumé
The cytoskeletal vimentin (Vim) and the alpha-enolase (ENO1) proteins are associated with autoimmune and inflammatory diseases. We previously documented that Vim is degraded by caspases and expressed at the cell surface of human apoptotic neutrophils. The aim of the present study was to monitor the expression of Vim, ENO1, and their citrullinated forms (cit-Vim, cit-ENO1) during the regulation of spontaneous human neutrophil apoptosis (SA) by the antiapoptotic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) and the proapoptotic anti-cancer drug arsenic trioxide (ATO). Although the degradation of Vim during SA was delayed by GM-CSF and accelerated by ATO, no significant degradation of cit-Vim, ENO1, and cit-ENO1 was observed. However, Vim, ENO1, cit-Vim, and cit-ENO1 are expressed at the cell surface of apoptotic neutrophils. These data further support the potential participation of neutrophils in autoimmune and inflammatory diseases as they might be an important source of autoantigens when they undergo apoptosis.
| Type de document: | Article |
|---|---|
| Informations complémentaires: | This work was supported partly by grants # 2017–0044 from the Institut de recherche Robert-Sauv´e en sant´e et en s´ecurit´e du travail (IRSST) and RGPIN-2018–05572 from Natural Sciences and Engineering Research Council of Canada (NSERC) |
| Mots-clés libres: | Alpha enolase; Apoptosis; Citrullination; Inflammation; Neutrophils; Vimentin |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 16 juin 2026 14:58 |
| Dernière modification: | 16 juin 2026 14:58 |
| URI: | https://espace.inrs.ca/id/eprint/16783 |
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