Ok, Linda; Vaillancourt, Cathy 
ORCID: https://orcid.org/0000-0003-0543-6244 et Oberlander, Tim F
(2025).
Impact of Depression and Selective Serotonin Reuptake Inhibitors (SSRIs) Treatment during Pregnancy on Iron Homeostasis-Related Protein Expression in Placental Tissue
In: IFPA 2025, 17th-20th September 2020, Erfurt-Jena, Germany.
Résumé
Objectives: Antenatal depression affects up to 20% of pregnancies and is
frequently treated with selective serotonin reuptake inhibitors (SSRIs).
Several studies have suggested an association between abnormal iron
status and depression. Pregnancy involves significant changes in iron
homeostasis, and disruptions in placental iron regulation—potentially
linked to SSRI treatment—may increase vulnerability in pregnant individuals with depressive symptoms. Despite the widespread use of SSRIs
during pregnancy, their impact on placental iron regulation remains unexplored. In this study, we investigate the potential relationship between
antenatal depression, SSRI treatment during pregnancy, and alterations in
the placental iron system.
Methods: Full-term placental tissues were obtained from the healthy
(n=18), depressed/SSRIs treated (n=18), and depressed/no SSRI (n=34)
pregnant individuals. Snap-frozen tissues were powdered, extracted, and
then digested with trypsin. Bottom-up proteomics analysis was conducted with data-independent LC-MS/MS and TripleTOF 5600 (Sciex).
Differential expression analysis was performed using the DEP package for
R, followed by the identification of iron-related proteins based on Reactome. The effect of depression and SSRIs were separately assessed by
comparing the expression between healthy vs. depressed/ no-SSRI and
depressed/no-SSRI vs. depressed/SSRI treated groups, respectively.
Results: In placentas from individuals with depression not treated with
SSRIs, compared to healthy controls, the expression of iron storage proteins (transferrin and lactotransferrin) and heme-regulating proteins
(hemoglobin subunits γ1, γ2, α, ϕ; α-hemoglobin stabilizing protein;
hemopexin; and biliverdin reductase B) was significantly increased (adj. p < 0.05). In contrast, the expression of iron transporters, including the
transferrin receptor, ferroportin, and LDL receptor-related protein 1, was
reduced. In placentas from depressed individuals treated with SSRIs,
compared to depressed/no-SSRI group, both iron storage and transport
proteins expression showed a reversed pattern.
Conclusion: Our findings suggest that maternal depression and SSRI
treatment during pregnancy may alter the placental iron transport and
homeostasis.
| Type de document: | Document issu d'une conférence ou d'un atelier |
|---|---|
| Informations complémentaires: | Affiche scientifique: P2.92 Placenta(2025) 171:e322 https://ifpa2025.com/wp-content/uploads/2025/09/Abstract-Book_IFPA2025-1.pdf |
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 16 juin 2026 14:52 |
| Dernière modification: | 16 juin 2026 14:52 |
| URI: | https://espace.inrs.ca/id/eprint/16781 |
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