Shaping the future of Leptospira serotyping

Giraud-Gatineau, Alexandre; Dagbo, Kouessi C; Pětrošová, Helena; Werts, Catherine M. L.; Veyrier, Frédéric ORCID: https://orcid.org/0000-0002-8574-0547 et Picardeau, Mathieu (2025). Shaping the future of Leptospira serotyping Journal of Medical Microbiology , vol. 74 , nº 9:002059. pp. 1-11. DOI: 10.1099/jmm.0.002059.

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Résumé

Leptospirosis is a re-emerging zoonosis caused by a diverse range of pathogenic Leptospira, which are divided into species, serogroups and serovars. Although advances in genomics have recently refined species classification, serotyping, which is based on the antigenic variability of lipopolysaccharides O-antigens, still relies heavily on traditional and labour-intensive methods. In addition, the molecular basis of serovar diversity is not fully understood, which poses challenges for rapid and accurate serovar and/or serogroup identification. However, identification of serovars remains crucial for epidemiological studies, surveillance, diagnostics, understanding host-pathogen interactions and vaccine development. In this review, we assess current techniques for Leptospira serovar and serogroup identification and explore emerging DNA-based methodologies for serovar and serogroup prediction.

Type de document:	Article
Informations complémentaires:	F.V. received a Junior 1, Junior 2 and Senior Research Scholar salary award from the Fonds de Recherche du Québec – Santé. K.D. received a studentship from the Fondation Arbour.
Mots-clés libres:	Diagnosis; epidemiology; leptospirosis; serology; strain typing
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	16 juin 2026 14:54
Dernière modification:	16 juin 2026 14:54
URI:	https://espace.inrs.ca/id/eprint/16662

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