Jamali, Hossein et Layeghkhavidaki, Hamed (2025). Toxin-antitoxin systems in Listeria monocytogenes: Regulation, stress adaptation, and pathogenesis Toxin Reviews , vol. 44 , nº 4. 459 -465. DOI: 10.1080/15569543.2025.2550416.
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Background and Aim:
Toxin-antitoxin (TA) systems contribute to bacterial persistence, stress adaptation, and antibiotic tolerance. While extensively studied in Escherichia coli and Staphylococcus aureus, their functions in Listeria monocytogenes, a major foodborne pathogen, remain poorly defined. This review synthesizes current knowledge of TA systems in L. monocytogenes.
Experimental Approach:
We conducted a comprehensive literature review of TA loci in L. monocytogenes, with comparative analyses to well-characterized systems in other pathogens, and evaluated available methodologies for TA investigation.
Key Findings and Conclusions:
Type II TA modules, notably MazEF, likely regulate stress responses through mRNA cleavage and integration with regulators such as σB and two-component systems. Bioinformatics and comparative data suggest roles in persistence, biofilm formation, and adaptation, though experimental validation is limited. We highlight critical gaps and propose TA systems as potential targets for controlling L. monocytogenes in food safety and clinical settings.
Impact Statement
This review highlights the emerging importance of toxin-antitoxin (TA) systems in Listeria monocytogenes, a key foodborne pathogen. By integrating current findings and identifying research gaps, we propose that TA systems are central to stress adaptation and persistence. Understanding these systems may lead to novel interventions to disrupt L. monocytogenes survival in food-processing environments and during infection. Our synthesis provides a foundation for experimental exploration and therapeutic innovation in bacterial stress regulation.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Toxin-antitoxin systems; persistence mechanisms; mRNA endoribonuclease; pathogen survival strategies; bacterial dormancy |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 08 juin 2026 20:10 |
| Dernière modification: | 08 juin 2026 20:10 |
| URI: | https://espace.inrs.ca/id/eprint/16649 |
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