Swaminathan, Sharada; Mai, Linh Thuy; Meli, Alexandre P; Carmona-Perez, Liseth; Charpentier, Tania; Lamarre, Alain 
ORCID: https://orcid.org/0000-0002-7913-871X; King, Irah L et Stäger, Simona ORCID: https://orcid.org/0000-0001-5508-9565
(2024).
LAG-3- and CXCR5-expressing CD4 T cells display progenitor-like properties during chronic visceral leishmaniasis
Cell Reports
, vol. 43
, nº 3:113879.
pp. 1-20.
DOI: 10.1016/j.celrep.2024.113879.
Résumé
Maintenance of CD4 T cells during chronic infections is vital for limiting pathogen burden and disease recrudescence. Although inhibitory receptor expression by CD4 T cells is commonly associated with immune suppression and exhaustion, such cell-intrinsic mechanisms that control activation are also associated with cell survival. Using a mouse model of visceral leishmaniasis (VL), we discovered a subset of lymphocyte activation gene 3 (LAG-3)-expressing CD4 T cells that co-express CXCR5. Although LAG3(+)CXCR5(+) CD4 T cells are present in naive mice, they expand during VL. These cells express gene signatures associated with self-renewal capacity, suggesting progenitor-like properties. When transferred into Rag1(-/-) mice, these LAG3(+)CXCR5(+) CD4 T cells differentiated into multiple effector types upon Leishmania donovani infection. The transcriptional repressor B cell lymphoma-6 was partially required for their maintenance. Altogether, we propose that the LAG3(+)CXCR5(+) CD4 T cell subset could play a role in maintaining CD4 T cell responses during persistent infections.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | CD4 T cell; Leishmania; chronic infection; progenitor-like; self-renewal; regulatory T cell; LAG-3; CXCR5; Tr1 |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 11 mars 2024 04:29 |
| Dernière modification: | 11 mars 2024 04:29 |
| URI: | https://espace.inrs.ca/id/eprint/15301 |
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