Dépôt numérique

Galectins in hematological malignancies

St-Pierre, Yves ORCID logoORCID: https://orcid.org/0000-0002-1948-2041 (2011). Galectins in hematological malignancies American Journal of Blood Research. , vol. 1 , nº 2. pp. 119-129.

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Carbohydrates are traditionally considered to be an important source of energy for living organisms. In the field of biol., they are defined as org. compds. composed of carbon, hydrogen, and oxygen that are organized into ring structures. The anal. of these structures and their functions has led to a new field of biol. called "glycobiol.". In the biomedical sciences, glycobiol. is rapidly emerging to be an integral part of complex biol. processes. Changes in glycan structures and the interactions of these structures with endogenous carbohydrate-binding proteins, known as lectins, are now considered to be potential biomarkers on cancer cells for monitoring tumor progression. Evidence suggesting that the interactions between lectins and their ligands have a major role in the different steps of cancer progression has accumulated at a rapid pace and has gained the attention of several oncologists. This is particularly true for galectin family members because changes in their expression levels correlate with alterations in cancer cell growth, apoptosis, and cell-cell and cell-matrix interactions. Here we provide an integrated view of the role of galectins in hematol. malignancies.

Type de document: Article
Mots-clés libres: galectins; lymphoma; apoptosis; gene profiling; immunosuppression
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 29 mars 2024 21:14
Dernière modification: 29 mars 2024 21:14
URI: https://espace.inrs.ca/id/eprint/15184

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