Dépôt numérique

Immunotoxicological effects of an activated-sludge-treated effluent on rainbow trout (Oncorhynchus mykiss)

Müller, C.; Ruby, Sylvia; Brousseau, Pauline; Cyr, Daniel G. ORCID logoORCID: https://orcid.org/0000-0002-6566-783X; Fournier, Michel et Gagné, François (2009). Immunotoxicological effects of an activated-sludge-treated effluent on rainbow trout (Oncorhynchus mykiss) Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology , vol. 150C , nº 3. pp. 390-394. DOI: 10.1016/j.cbpc.2009.06.004.

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Municipal effluents are often treated by biol. processes designed to enhance natural biodegrdn. that introduce important changes to the local bacterial community and contaminant status. The purpose of this study was to examine the immunotoxicol. effects of an activated sludge treated urban effluent on rainbow trout (Oncorhynchus mykiss). Trout specimens were exposed to increasing concns. of the effluent at 0.1%, 1% and 10% vol./vol. dilns. for 30 days at 15 °C. After the exposure period, the leukocytes were isolated from the anterior kidney and the following parameters were detd.: phagocytic activity, lymphoblastic transformation and natural cytotoxic activity. The results revealed that phagocytic activity was not significantly affected by the biol. treated effluent. Natural cytotoxic activity was significantly increased at an effluent threshold concn. of 3% vol./vol. at an effector/target cell ratio of 20:1 and 40:1. Stimulated lymphocyte T and B proliferation was significantly decreased at a threshold concn. of 0.3%. However, neither the unstimulated lymphocyte T nor lymphocyte B proliferation was significantly affected by effluent exposure. The results suggest that the activated-sludge-treated effluent increased cell-mediated cytotoxic activity with a concomitant decrease in cells responsible for antibody and cytokine prodn., indicating that the immune system of rainbow trout was directed towards the elimination of transformed cells, virus-infected cells and protozoan parasites at the expense of cytokine and antibody prodn.

Type de document: Article
Mots-clés libres: Municipal effluents; Immunotoxicity; Rainbow trout; Phagocytosis; Natural cell cytotoxicity; Lymphocyte
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 01 juill. 2024 02:01
Dernière modification: 01 juill. 2024 02:01
URI: https://espace.inrs.ca/id/eprint/14986

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