Liz, Rafael; Pereira, Danielle Fontana; Horst, Heros; Dalmarco, Eduardo Monguilhott; Dalmarco, Juliana Bastos; Simionatto, Edésio Luiz; Pizzolatti, Moacir Geraldo; Girard, Denis 
ORCID: https://orcid.org/0000-0002-3342-5027 et Fröde, Tânia Silvia
(2011).
Protected effect of Esenbeckia leiocarpa upon the inflammatory response induced by carrageenan in a murine air pouch model
International Immunopharmacology
, vol. 11
, nº 12.
pp. 1991-1999.
DOI: 10.1016/j.intimp.2011.08.009.
Résumé
This study was conducted to investigate the anti-inflammatory efficacy of Esenbeckia leiocarpa against the inflammation caused by the carrageenan using a murine air pouch model.
Material and methods:
The effects of the crude hydroalcoholic extract (CHE), fractions (n-hexane (Hex) and ethyl acetate (AcOEt)), subfractions (polar (Pol) and nonpolar (Nonpol)), or isolated compounds (dihydrocorynantheol (DHC) and beta-sitosterol (β-Sit)) isolated from CHE upon leukocytes, exudate, myeloperoxidase (MPO) adenosine-deaminase (ADA), nitrate/nitrite (NOx), interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and inhibitory kappa-B-alpha (IκB-α) degradation were evaluated. The CHE, Alk, Pol, Nonpol, DHC and β-Sit, inhibited leukocytes, exudate, MPO and ADA, NOx, IL-1β, and TNF-α (P < 0.05). The Hex and AcOEt fractions inhibited all of the proinflammatory parameters, except the exudate. The compound DHC prevented the IκB-α degradation.
Conclusion:
E. leiocarpa possesses important anti-inflammatory properties. These inhibitory effects occurred along with the downregulation of nitric oxide, IL-1β and TNF-α levels. The isolated compounds DHC and β-Sit may be partially responsible for these anti-inflammatory effects.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Esenbeckia leiocarpa; Air pouch model; Anti-inflammatory effect; Leukocyte; Cytokines; NF-κB |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 27 mars 2024 15:15 |
| Dernière modification: | 27 mars 2024 15:15 |
| URI: | https://espace.inrs.ca/id/eprint/14913 |
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