Dépôt numérique

Bidirectional interactions between bone metabolism and hematopoiesis

Despars, Geneviève et St-Pierre, Yves ORCID logoORCID: https://orcid.org/0000-0002-1948-2041 (2011). Bidirectional interactions between bone metabolism and hematopoiesis Experimental Hematology , vol. 39 , nº 8. pp. 809-16. DOI: 10.1016/j.exphem.2011.04.008.

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Interactions between hematopoiesis and bone metabolism have been described in various developmental and pathological situations. Here we review this evidence from the literature with a focus on microenvironmental regulation of hematopoiesis and bone metabolism. Our hypothesis is that this process occurs by bidirectional signaling between hematopoietic and mesenchymal cells through cell adhesion molecules, membrane-bound growth factors, and secreted matrix proteins. Examples of steady-state hematopoiesis and pathologies are presented and support our view that hematopoietic and mesenchymal cell functions are modulated by specific microenvironments in the bone marrow.

Type de document: Article
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 24 mars 2024 21:45
Dernière modification: 24 mars 2024 21:45
URI: https://espace.inrs.ca/id/eprint/14590

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