Dépôt numérique

The Search for Antidotes Against Ricin

Botelho, Fernanda Diniz; Franca, Tanos Celmar Costa et Laplante, Steven ORCID logoORCID: https://orcid.org/0000-0003-2835-5789 (2024). The Search for Antidotes Against Ricin Mini-Reviews in Medicinal Chemistry . DOI: 10.2174/0113895575270509231121060105. (Sous Presse)

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The castor plant (Ricinus communis) is primarily known for its seeds, which contain a unique fatty acid called ricinoleic acid with several industrial and commercial applications. Castor seeds also contain ricin, a toxin considered a chemical and biological warfare agent. Despite years of investigation, there is still no effective antidote or vaccine available. However, some progress has been made, and the development of an effective treatment may be on the horizon. To provide an updated overview of this issue, we have conducted a comprehensive review of the literature on the current state of research in the fight against ricin. This mini-review is based on the reported research and aims to address the challenges faced by researchers, as well as highlight the most successful cases achieved thus far. Our goal is to encourage the scientific community to continue their efforts in this critical search.

Type de document: Article
Mots-clés libres: Drug design; Ribosome-inactivating protein; Ricin inhibitors; chemical warfare; medicinal chemistry; ricin A chain
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 27 févr. 2024 19:27
Dernière modification: 27 févr. 2024 19:27
URI: https://espace.inrs.ca/id/eprint/14332

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